Comparison of the Effectiveness of Hepatoprotectors of Black Cumin Extract and Temulawak Extract in SGOT and SGPT Induced by Paracetamol

Main Article Content

Fadhilla Qudsi Ramadhani
Des Suryani

Abstract

ABSTRACT


 


Background: Paracetamol is used for analgesics and antipyretics, its use can damage the liver. Herbs that prevent liver disorders are curcuma. Black cumin can increase antioxidants. Objective: This study aims to compare the effectiveness of black cumin extract and curcuma against the liver function of paracetamol-induced rats. Methods: A laboratory experimental study posttest only with control group design. A total of 4 groups were treated for 7 days. SGOT and SGPT levels were tested. Data analysis using one-way ANOVA post hoc Games-Howell.Results: K- and K+ groups in this study showed an increase in SGOT SGPT levels. There is an effect of giving a dose of paracetamol 500 mg/kgBB on liver damage, there is no differences and significant effect in the administration of black cumin extract and curcuma dose 500 mg/kgBB to the liver of rats that have been induced by paracetamol (p>0.05). Conclusion: Giving paracetamol has an influence on rat liver damage. And there was no difference in the effects of hepatoprotector in groups given black cumin extract and curcuma in paracetamol-induced rats.


 


Keywords: black cumin, curcuma, paracetamol, SGOT, SGPT

Article Details

How to Cite
Ramadhani, F., & Suryani, D. (2020). Comparison of the Effectiveness of Hepatoprotectors of Black Cumin Extract and Temulawak Extract in SGOT and SGPT Induced by Paracetamol. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 8(2), 29-35. https://doi.org/10.53366/jimki.v8i2.127
Section
Research Article

References

1. D D. Dictionary of Flavors. 2nd Editio. (Blackwell W, ed.). New Jersey; 2009.
2. Puri SK, Habbu PV, Kulkarni PV, Kulkarni VH. Hepatoprotective Activity Of Fungal Endophytic Fractions Of Andrographis Paniculata (Burm. F.) Wall Nees. Leaves In Paracetamol And Ethanol Induced Hepatotoxicity. Int J Pharm Sci Res. 2019;10(1):97-107.
3. George M, Joseph L, Deshwal N, Joseph J. Hepatoprotective activity of different extracts of Pterospermum acerifolium against paracetamol induced hepatotoxicity in albino rats. 2016;5(3):32-36.
4. Khan MA, Afzal M. Chemical composition of Nigella sativa Linn : Part 2 Recent advances. Inflammopharmacology. 2016;24(2):67-79.
5. Kazmi A, Khan MA. Biotechnological approaches for production of bioactive secondary metabolites in Nigella sativa : an up-to-date review. 2019;6(2):172-195.
6. Kushwah D., Salman M., Singh P, Verma V., Ahmad A. Protective Effect of Ethanolic Extract of Nigella Sativa Seed in Paracetamol Induced Acute Hepatotoxicity In vivo. Pakistan J Biol Sci. 2014;17 (4):517-522.
7. Eidi A, Zarin Ghalam J, Rezazade SA, Adeli R. Hepatoprotective effect of Berberis vulgaris L. extract on CCl4-induced toxicity in rats. Trauma Mon. 2011.
8. Hadinata M teguh. Uji Efek Hepatorepair Ekstrak Temulawak (Curcuma Xanthorrhiza Roxb) pada Tikus Putih Jantan Galur Wistar yang diinduksi Paracetamol. 2016.
9. Hayat MA. Autophagy : Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Volume 3 - Role in Specific Diseases. Academic Press; 2013.
10. Eldutar E, Kandemir FM, Kucukler S, Caglayan C. Restorative effects of Chrysin pretreatment on oxidant – antioxidant status , inflammatory cytokine production , and apoptotic and autophagic markers in acute paracetamol-induced hepatotoxicity in rats : An experimental and biochemical study. 2017;(February):4-9.
11. Adam GO, Rahman MM, Lee S, et al. Hepatoprotective effects of Nigella sativa seed extract against acetaminophen-induced oxidative stress. Asian Pac J Trop Med. 2016;9(3):221-227.
12. Devaraj S, Ismail S, Ramanathan S, Yam MF. Investigation of Antioxidant and Hepatoprotective Activity of Standardized Curcuma xanthorrhiza Rhizome in Carbon Tetrachloride-Induced Hepatic Damaged Rats. 2014;2014.
13. Klarissa C. Uji Efek Pemberian Ekstrak Temulawak (Curcuma Xanthorrhiza Roxb.) terhadap Gambaran Histopatologi Ginjal Tikus Putih Jantan Galur Wistar Yang Diinduksi Parasetamol. 2016.