Association of Uric Acid Level With Severe Preeclampsia in Pregnancy Women in RSUD Dr. H Abdul Moeloek Province Lampung
Article Sidebar
Main Article Content
Abstract
Background: Preeclampsia is a syndrome of pregnancy after 20 weeks gestation and is one of obstetric emergencies. An early detection to diagnosis of preeclampsia is needed to avoid a poor prognosis of preeclampsia. Uric acid during pregnancy is one of preeclampsia biomarkers that can be used as a diagnostic assessment of preeclampsia. The purpose of this study is to know the association of uric acid level with severe preeclampsia in pregnancy women in RSUD Dr. H. Abdul Moeloek Lampung Province.
Method: The design of this research is case control. Case population were pregnant women with preeclampsia and control population were pregnant women without preeclampsia. sample of case consist 31 respondents and case-control consist 31 respondents. Incidence preeclampsia data obtained while the examination acid levels obtained from laboratory tests. Chi-Square analysis is used to do bivariate analysis.
Results: Pregnant women with preeclampsia have elevated uric acid levels of (74.2%) than the control (without preeclampsia) group (35.5%). Based on bivariate analysis, the value of p = 0.0005 and OR 5.227 (95% CI = 1.7 to 15.5).
Discussion: The failure of abnormal spiral artery remodeling in preeclampsia causes placental cellular ischemia which will increase the activity of Xanthine Oxidase which can increase uric acid production from maternal, fetal or placental tissues.
Conclusion: There is a assosiation high levels of uric acid during pregnancy that increased the risk of preeclampsia by 5 times when compared with normal uric acid levels during pregnancy.
Keywords: preeclampsia, pregnancy, uric acid
Article Details
References
2. WHO, WORLDBANK. Trends in Maternal Mortality : 1990 to 2010. Organization [Internet]. 2012;32(5):1–55. Available from: http://whqlibdoc.who.int/publications/2010/9789241500265_eng.pdf
3. Kementrian Kesehatan Republik Indonesia. Rencana operasional promosi kesehatan ibu dan anak. Jakarta: Pusat promosi kesehatan; 2010.
4. Departemen Kesehatan RI. Profil kesehatan Indonesia 2005. Jakarta: Departemen Kesehatan RI 2007; 2007.
5. Young BC, Levine RJ, Karumanchi SA. Pathogenesis of preeclampsia. Annu Pathol Mech Dis. 2010;5:173–92.
6. Sumanti N, Noormartany, Alamsyah M. Kadar Asam Urat Serum sebagai Biomarker Preeklamsi Serum Levels of Uric Acid as a Biomarker in Preeclampsia. Mkb [Internet]. 2013;45(2):98–104. Available from: journal.fk.unpad.ac.id/index.php/mkb/article/download/89/pdf_28
7. Bainbridge SA, Roberts JM. Uric Acid as a Pathogenic Factor in Preeclampsia. Placenta. 2008;29(SUPPL A):67–72.
8. Bellomo G, Venanzi S, Saronio P, Verdura C, Narducci PL. Prognostic Significance of Serum Uric acid in Women With Gestational Hypertension. Hypertension. 2011;58(4):704–8.
9. Tejal P, Astha D. Relationship of Serum Uric Acid Level to Maternal and Perinatal Outcome in Patients with Hypertensive Disorders of Pregnancy. Gujarat Med J. 2014;69(2):1–3.
10. Kementerian Kesehatan RI. Infodatin Pusat Data dan Informasi Kementerian Kesehatan RI [Internet]. Pusat Data dan Informasi Kementrian Kesehatan RI : Penyebab Kematian Ibu. 2014. p. 8. Available from: www.depkes.go.id/resources/download/pusdatin/infodatin/infodatin-ibu.pdf
11. Manik IN, Sari RDP, Wulan AJ. Hubungan Status Preeklampsia dengan Kejadian Perdarahan Postpartum pada Ibu Bersalin di RSUD Dr H Abdul Moeloek Provinsi Lampung Periode 1 Juli 2014 - 30 Juni 2015. Majority. 2017;6:51–7.
12. Dinas Kesehatan Pemerintah Provinsi Lampung. Profil Kesehatan Provinsi Lampung Tahun 2015. 2016. 1–252 p.
13. Diwan J, Shah C, Dixit R, Anand AK. A Comparative Study of Serum Uric Acid Level in Normal Pregnancy , and Pregnancy Induced Hypertension. IJMEDPH. 2011;1(1):39–42.
14. Singh AK, Kumar R, Singh VK, Srivastava S, Sharma A. Serum uric acid levels in pregnancy induced hypertension preeclampsia. Int J Clin Biochem Res. 2018;5(3):365–8.
15. Zangana JM, Hamadamen AI. Serum Uric Acid as a Predictor of Perinatal Outcome in Women with Pre-Eclampsia. Int J Med Res Heal Sci. 2018;7(3):168–74.
16. Pettit F, Brown MA. The management of pre-eclampsia: What we think we know. Eur J Obstet Gynecol Reprod Biol [Internet]. 2012;160(1):6–12. Available from: http://dx.doi.org/10.1016/j.ejogrb.2011.09.049
17. Gathiram P, Moodley J. Pre-eclampsia : its pathogenesis and pathophysiolgy. Cardiovasc J Afr. 2016;27(2):71–8.
18. Gallery E, Hunyor S, Gyory A. Plasma volume cntraction: a significant factor in both pregnancy-assiciated hypertension (pre-eclampsia) and chronic hypertension in pregnancy. Q J Med. 1979;48:593–602.
19. Khurshid R, Shamsi A, Fayyaz I, Zia M. Maternal Serum Uric Acid Level during Pregnancy : A Biomarker for Preeclampsia. PJMHS. 2016;10(2):413–6.
20. Kondareddy T, Prathap T. Uric acid as an important biomarker in hypertensive disorders in pregnancy. Int J Reprod Contraception, Obstet Gynecol. 2016;5(12):4382–4.
21. Bellomo G. Serum uric acid and pre-eclmpsia: an update. Expert Riviews. 2014;5(3).
22. Toshniwal S, Lamba AR. Serum uric acid as marker of severity of pre-eclampsia. Int J Reprod Contraception, Obstet Gynecol. 2017;6(11):4915–7.
23. Saleh F, Shukar-ud-din S, Soomro N. Serum uric acid as predictor model for pre eclampsia. Dep Obstet Gynaecol Unit II Dow Univ Heal Sci Karachi. 2010;26(3):246–51.
24. Niraula A, Lamsal M, Majhi S, Khan SA, Basnet P. Significance of Serum Uric Acid in Pregnancy Induced Hypertension. J Natl Med Assoc [Internet]. 2017;1–5. Available from: http://dx.doi.org/10.1016/j.jnma.2017.01.009