POTENSI UMBILICAL CORD BLOOD DERIVED STEM CELLS DALAM MEMPERBAIKI KERUSAKAN OTAK AKIBAT PENYALAHGUNAAN NARKOTIKA

Abstract

ntroduce: The prevalence of drug abuse in the world has increased. In Indonesia, The
number of cases of narcotics abuse has increased in the last 5 years while those
included in other additives decreased the number of cases. Opiates, one of narcotics,
have the most evident addictive effects, involving tolerance, withdrawal, and a high rate
of relapse. Beside that, the mechanisms involved in the neurotoxicity of these drugs
include oxidative stress, apoptosis, mitochondrial dysfunction, and inhibition of
neurogenesis. Neural system is incapable to self-repair and renewal. In contrast, neural
stem cells can repair and treat the neurogical disorders. Stem cells can be self-adaptive
to the host environment providing multi-folded roles, from neuronal protection,
neurotrophic effect to direct neuronal replacement to facilitate the repair and regenerative process of the injured CNS following brain damage. Discussion: Human cord bloodstem cell express nestin which effective in promoting differentiation of oligodendrocytes, astroglia, and neurons nd recruit  them to repair damaged area in brain caused by drug abuse.

Conclusion: Umbilical cord blood derived stem cells can be an alternative,
innovative and effective therapy to repair repairing brain demage caused by narcotics
abuse