PERAN WHEY-ACIDIC-PROTEIN FOUR DISULFIDE CORE DOMAIN 2 (WFDC2) SEBAGAI BIOMARKER MUTAKHIR DALAM DETEKSI DAN DIAGNOSIS DINI KANKER OVARIUM

Abstract

Introduction: Ovarian cancer has a major role as the causes of prevalence and deaths
worldwide and has been estimated at 2025 they will rise over heart disease as the largest
cause of death. Indonesia is one of the developing countries that have the death rate
from ovarian cancer is the third-highest in Asia after China and India. The prevalence of
ovarian cancer could be suppressed if the detection and early diagnosis can be
established. However, detection of which is currently used is CA125 is still inadequate as
a diagnosis of early-stage ovarian cancer because this biomarker has high sensitivity and
specificity only at an advanced stage which is the stage is already quite late to be treated.
Discussion: The overexpression WFDC in vitro and in vivo indicate a significant
contribution to the proliferation, cell growth rate, invasive capability, and independent
growth in tumor cells. Additionally, WFDC2 has a higher sensitivity and specificity in
early-stage cancer (stage 1 and 2) compared to CA125 and combination of
CA125+WFDC2 so it is very advantageous for clinician to detect ovarian cancer earlier.
Conclusion: WFDC2 can be used as a biomarker for the detection and early diagnosis of
ovarian cancer.