Potensi Pemanfaatan Serum Mir 122-5p Sebagai Biomarker Dalam Deteksi Dini Infark Miokard Akut Pada Pasien Lanjut Usia

Main Article Content

Muhammad Abi Ghoffari Siregar


Acute myocardial infarction is the first manifestation of CAD which is the leading cause of death worldwide. The increasing incidence is often associated with increasing age where eldery are mostly affected with this disease. Although there are several biomarkers such as troponin I and T in detecting the risk of developing AMI, it has been found that populations over 70 years have elevated troponin I levels and increased troponin T levels in non-AMI cases. Because of that, a specific biomarker that can specifically detect AMI is needed. This literature review is aimed to discuss the possibility by using miR-122-5p serum for specific biomarker in detecting AMI in eldery population. The literature search was conducted based on journal searching related to the topic such as, PubMed, Science Direct, and Google Scholar. Based on the literature research we have done and our topic, we have obtained the results as follows. Pathogenesis of AMI, the underlying mechanism of miR-122-5p in association with AMI, the specificity of miR-122-5p for AMI, and the comparison of miR-122-5p with other AMI biomarkers. From the pathogenesis of AMI, we have obtained the basis of the disease, the underlying mechanism explains the potential relation to AMI and the detection, through the specificity we can see how it may be effective as a biomarker, and the comparison may reveal it’s potential and how it compares to other biomarkers.

Article Details

How to Cite
Siregar, M. A. (2024). Potensi Pemanfaatan Serum Mir 122-5p Sebagai Biomarker Dalam Deteksi Dini Infark Miokard Akut Pada Pasien Lanjut Usia. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 10(2), 14-21. https://doi.org/10.53366/jimki.v10i2.529
Article Review


1. Zhang B, Li B, Qin F, Bai F, Sun C, Liu Q. Expression of serum microRNA-155 and its clinical importance in patients with heart failure after myocardial infarction. Journal of International Medical Research. 2019;47:6294-302.
2. Chen Z, Li C, Lin K, Zhang Q, Chen Y, Rao L. MicroRNAs in acute myocardial infarction: Evident value as novel biomarkers?. Anatol J Cardiol. 2018;19:140-7.
3. Vazquez-Oliva G, Zamora A, Ramos R, Marti R, Subirana I, Grau M, et al. Acute myocardial infarction population incidences and mortality rates, and 28-day cases fatality in older adults: The REGICOR study. Rev Esp Cardiol. 2018;71:718-25.
4. Smilowitz NR, Mahajan AM, Roe MT, Hellkamp AS, Chisswell K, Gulati M, et al. Mortality of myocardial infarction by sex, age, and obstructive coronary artery disease status in the ACTION Registry–GWTG (Acute coronary treatment and intervention outcomes network registry–get with the guidelines). Circulation. 2017;10:1-8.
5. Wang B, Li Y, Hao X, Yang J, Han X, Li H, et al. Comparison of the clinical value of miRNAs and conventional biomarkers in AMI: A systematic review. Front Genet. 2021;12:1-12.
6. Rains MG, Laney CA, Bailey AL, Campbell CL. Biomarkers of acute myocardial infarction in the elderly: troponin and beyond. Clinical Interventions in Aging. 2014;9:1081-90.
7. Eggers KM, Lind L, Ahlström H. Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects. Eur Heart J. 2008;29:2252–8.
8. Tilea I, Varga A, Serban RC. Past, present, and future of blood biomarkers for the diagnosis of acute myocardial infarction-promises and challenges. Diagnostics. 2021;11:1-19.
9. Anderson JL M DA. ACUTE MIOCARDIO The New Englad Journal. N Engl J Med. 2017;21(367):2053–64.
10. Eisen A, Giugliano RP, Braunwald E. Updates on acute coronary syndrome: A review. JAMA Cardiol. 2016;1(6):718–30.
11. Makki N, Brennan TM, Girotra S. Acute coronary syndrome. J Intensive Care Med. 2015;30(4):186–200.
12. Cortez-Dias, N., Costa, M. C., Carrilho-Ferreira, P., Silva, D., Jorge, C., Calisto, C., … Enguita, F. J. (2016). Circulating miR-122-5p/miR-133B ratio is a specific early prognostic biomarker in acute myocardial infarction. Circulation Journal, 80(10), 2183–2191.
13. Wang, Y., Chang, W., Zhang, Y., Zhang, L., Ding, H., Qi, H., … Li, P. (2019). Circulating miR-22-5p and miR-122-5p are promising novel biomarkers for diagnosis of acute myocardial infarction. Journal of Cellular Physiology, 234(4), 4778–4786.
14. Badacz, R., Kleczyński, P., Legutko, J., Żmudka, K., Gacoń, J., Przewłocki, T., & Kabłak-Ziembicka, A. (2021). Expression of mir-1-3p, mir-16-5p and mir-122-5p as possible risk factors of secondary cardiovascular events. Biomedicines, 9(8).
15. Dayan, N., Schlosser, K., Stewart, D. J., Okano, M., Grand’Maison, S., & Pilote, L. (2016). DECREASED CIRCULATING LEVELS OF THE LIPID-REGULATING MIR-122 ARE ASSOCIATED WITH PRIOR PREECLAMPSIA IN WOMEN WITH PREMATURE ACUTE CORONARY SYNDROME. Canadian Journal of Cardiology, 32(10), S109.
16. Singh, S., de Ronde, M. W. J., Kok, M. G. M., Beijk, M. A., De Winter, R. J., van der Wal, A. C., … Pinto-Sietsma, S.-J. (2020). MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability. Open Heart, 7(1), e001223.
17. Li L, Li S, Wu M, Chi C, Hu D, Cui Y, et al. Early diagnostic value of circulating microRNAs in patients with suspected acute myocardial infarction. J Cell Physiol. 2019;234(8):13649–58.
18. Yao X-L, Lu X-L, Yan C-Y, Wan Q-L, Cheng G-C, Li Y-M. Circulating miR-122-5p as a potential novel biomarker for diagnosis of acute myocardial infarction. Int J Clin Exp Pathol [Internet]. 2015;8(12):16014–9. Tersedia pada: http://www.ncbi.nlm.nih.gov/pubmed/26884877