ANGIOTENSIN CONVERTING ENZYME INHIBITOR SEBAGAI TERAPI PASIEN HIPERTENSI PRIMER DENGAN OBESITAS

Abstract

Hypertension and obesity are the diseases that’s corelate to each other. The Bridge that
connects between hypertension and obesity lies on Renin Angiotensin System (RAS) and
leptin and adiponectin hormone system. RAS function to regulate the osmolarity of the
blood circulation to control blood pressure. Leptin is a hormone that inhibit food intake.
Adiponectin secreted by adipose cells to regulate blood glucose and performing the
oxidation of fatty acid. In recent studies found that there’s a correlation between
angiotensinogen with adiponectin. Then the question emerge about an intervention on RAS
could have an effect on adiponectin, the hormone that’s corelate to obesity. A study from
Fontana et.al found that there’s a correlation on using ACE inhibitor with leptin and
adiponectin. Subjects with primary hypertension with 8 weeks enalapril therapy shows an
increase in adiponectin level, whilst the control group didnt show any significant change.
There isn’t any correlation between subject and control on leptin level. This journal may
present the theories that may lead to explaining about the correlation between hypertension
and obesity, and if ACE Inhibitor is the right therapy for primary hypertension patient with
an obesity or not.